NSMS National Medical Toxicology Laboratory

Led by Lewis Nelson, MD

Advancing Precision Toxicology Through Autonomous Science, AI, and Mechanistic Medicine

The NSMS National Medical Toxicology Laboratory is a next-generation translational toxicology center integrating autonomous experimentation, mechanistic systems biology, AI-enabled inference, and real-world clinical toxicology to understand, predict, and mitigate complex human toxic exposures.

Led by internationally recognized medical toxicologist Lewis Nelson, MD, the laboratory combines computational toxicology, molecular profiling, digital twin modeling, autonomous robotics, and causal inference systems to transform toxicology from reactive exposure analysis into predictive and mechanistically explainable precision toxicology.

The laboratory focuses on understanding how environmental toxins, pharmaceuticals, industrial chemicals, micro/nanoplastics, biologic agents, and emerging contaminants interact with molecular, cellular, organ, and whole-body physiology.

Mission

To establish an autonomous, continuously learning toxicology ecosystem capable of predicting, simulating, validating, and optimizing human responses to toxic exposures across biologic scales.

Core Scientific Programs

Autonomous Toxicology Systems

Development of closed-loop toxicology architectures integrating:

  • AI-guided experimental design

  • Autonomous robotics (DrRobots™)

  • Real-time physiologic sensing

  • Mechanistic digital twins

  • Organ-on-chip validation systems

  • Multiscale molecular profiling

  • Continuous causal inference

Environmental & Micro/Nanoplastic Toxicology

The laboratory investigates:

  • Microplastic and nanoplastic bioaccumulation

  • Environmental exposure pathways

  • Organ-specific toxicity

  • Cellular trafficking mechanisms

  • Barrier transport dynamics

  • Chronic inflammatory responses

  • Neurotoxicologic mechanisms

  • Immune-system dysregulation

Platforms include:

  • Longitudinal PET/CT imaging

  • Spatial omics

  • Single-cell transcriptomics

  • Autonomous exposure systems

  • Mechanistic PBPK modeling

  • Organ-on-chip microphysiology

Precision Clinical Toxicology

Clinical toxicology programs focus on:

  • Drug toxicity prediction

  • Personalized antidote optimization

  • ICU toxicology monitoring

  • Real-time physiologic modeling

  • Predictive overdose analytics

  • AI-guided toxicologic intervention

  • Mechanistic PK/PD simulation

Systems integrate patient-specific digital twins capable of forecasting toxic trajectories before irreversible physiologic injury develops.

Core Technologies

aMks™: 1,966-marker molecular profiling

aEyes™: Multiscale imaging and physiologic perception

aTwins™: Mechanistic digital twin modeling

aTox™: Autonomous causal inference engine

aArmour™: Organ-on-chip validation systems

DrRobots™: Autonomous experimentation and robotic intervention

R&D Areas

  • Medical Toxicology

  • Computational Toxicology

  • Environmental Health

  • Nanotoxicology

  • Pharmacology

  • Precision Medicine

  • ICU Toxicology

  • Autonomous Experimental Systems

  • Mechanistic Systems Biology

  • AI-Driven Therapeutics

Leadership

Lewis Nelson, MD

Director, NSMS National Medical Toxicology Laboratory

Lewis S. Nelson, MD, is an internationally recognized medical toxicologist specializing in emergency medicine, pharmacology, toxicologic systems biology, and translational toxicology. His work focuses on integrating mechanistic toxicology, computational modeling, and AI-enabled healthcare systems to advance precision toxicology and autonomous medicine.

The Near Future of Toxicology

The NSMS National Medical Toxicology Laboratory is building the future of autonomous toxicology — a continuously adaptive intelligence infrastructure capable of understanding, predicting, and optimizing human responses to toxic exposures across molecular, cellular, organ, and whole-body scales.